葛根麻黄颗粒大鼠长期毒性试验

The long-term toxicity of Gegen Mahuang Granules (葛根麻黄颗粒) in rats

目的观察连续给予葛根麻黄颗粒对大鼠产生的毒性及严重程度。方法80g/kg、40g/kg、20g/kg连续灌胃给药1个月,停药后继续观察2周,测试大鼠体重、进食量、血液学、血液生化学,脏器系数及病理组织学变化。结果80g/kg剂量时使大鼠进食量及体重减少,血红蛋白降低,40g/kg和20g/kg剂量时对大鼠各项指标无明显影响。结论葛根麻黄颗粒在80g/kg剂量时可引起大鼠食量减少,体重减轻及血红蛋白降低等轻度毒性作用。葛根麻黄颗粒对大鼠的安全剂量为40g/kg。

Objective： To observe the long-term toxicity and severity occurred after successive administration of Gegen Mahuang Granules（GMG） in rats. Methods ： Rats was successively received GMG in doses of 80, 40, and 20 g/kg for 1 morth. Observed for 2 weeks after the withdrawal of the drug. The rats＇ body weight, food intake, hematology, hematic biochemistry, and organ coefficients were measared, and were observed the pathological and histological changes. Results： GMG in the dose of 80 g/kg decreased the food intake and body weight of rats, reduced hemoglobins in rats. GMG in the doses of 40 g/kg and 20 g/kg had no significant effects on the various markers of rats. Conclusions： GMG in the dose of 80 mg/kg may have mild toxicity of decreasing the food intake and body weight of rats, and of reducing hemoglobins in rats. The safety dose of GMG for rats is 40 g/kg.