维心康泰胶囊对高脂血症大鼠血液流变性及血脂的影响

Effects of Weixinkangtai capsule (维心康泰胶囊) on the hemorheology and blood lipid in hyperlipidemia rats

目的研究维心康泰对高脂血症大鼠血液流变性及血脂的影响。方法用脂肪乳制备高脂血症大鼠模型,比较维心康泰与多烯康对高脂血症大鼠血液流变学及血脂的影响。结果维心康泰40mg/kg及160mg/kg与多烯康80mg/kg均能明显降低高脂血症大鼠的血液粘度,明显降低血清中总胆固醇(TC)和甘油三酯(TG)的含量,显著提高高密度脂蛋白(HDL)及(HDL/TC)的比值(P<0.01),且作用强于多烯康;但对红细胞压积(HCT)和血沉(ESR)无明显影响。结论维心康泰具有改善血液流变学、调血脂和抗动脉粥样硬化的作用。

Objective：To observe the effects of Weixinkangtai （WXKT） capsule on the hemorheology and bloodlipid in hyperlipidemia rats. Methods ： The model of hyperlipidemia rats was made by fatty emulsion, to compare the effects of Weixinkangtai capsule and Duoxikang capsule on the hemorheology and blood-lipid in hypedipidemia rats. Results： Weixinkangtai 40mg/kg, 160mg/kg and Duoxikang 80mg/kg can reduce the bloodviseosity observably in hyperlipidemia rats（ P 〈 0.01 ）. The content of total cholesterol（TC） and triglyceride （TG） in serum were re- duced evidently （ P 〈0.01 ） , the content of high density lipoprotein （HDL） and the ratio of HDL and TC （HDL/TC） were increased observably （ P 〈 0.01 ） ; the process of Weixinkangtai capsule is mightier than DuoXiKang capsule （ P 〈0.01 or P 〈 0. 05 ） ; but its has not effects for the the hematocrit （HCT） and erythroeyte sedimentation rate （ESR）. Conclusion： Weixinkangtai capsule has the action of ameliorating hemorheology, adjusting bloodlipid.