灵芪蠲肝液对血清肝纤维化指标和NO的影响

The Effect of Lingqijuangan Liquor (灵芪蠲肝液) on serum hepatic fibrosis indexes and NO

目的研究灵芪蠲肝液对血清肝纤维化指标和NO的影响。方法四氯化碳皮下注射复制肝纤维化模型,测血清NO及纤维化指标HA、LN、PCⅢ、CⅣ;并取肝组织做病理检查。结果四氯化碳慢性肝损伤时,灵芪蠲肝液可降低NO、HA、LN、PCⅢ、CⅣ;减轻肝脂肪变性,减少纤维组织增生,促进肝细胞再生。结论灵芪蠲肝液能减少肝纤维化指标的含量,减少NO的产生。

Objective： To observe the effect of Lingqijuangan Liquor（LQL） on serum liver fibrosis indexes and NO. Methods： The model of hepatic fibrosis was induced by 40% carbon tetrachloride oil liquor 3ml/kg se. The changes of blood serum ALT, AST, TP, ALB, GLO, ALB/ GLO, NO, serum fibrosis index hyaluronie acid （ HA）, laminine （ LN ）, procollagen Ⅲ （ PCⅢ ） , collagen Ⅳ （ CⅣ） were measured. Take liver tissue to do pathological examination. Results： Compaired with model group ,LQL can notably decrease ALT, AST, HA, LN, PCⅢ, and C Ⅳ and significantly elevate ALB when livers were chronic damaged, the difference was striking （ p 〈 0.05 ）. Pathological examination find that LQL can lighten liver fat denaturalization and reduce fibrous tissue hyperplasia and accelerate liver cell rebirth. Conclusion： The hepatic fibrosis indexes and NO were decreased by LQL. So LQL had the effect of prophylaxes and therapy about CCl4 induced hepatic fibrosis.