不同心绞痛患者血清脑钠肽的临床意义

The Clinical Value of the Serum BNP in the Angina Pectoris Patients

目的:探讨心绞痛患者血清脑钠肽(BNP)水平在评估心功能以及冠状动脉病变程度方面的临床价值。方法:经选择性冠状动脉造影(CAG)证实为心绞痛的患者68例,其中稳定型心绞痛(SA)患者32例,不稳定型心绞痛(UA)患者36例,根据NYHA标准分为心功能Ⅰ～Ⅳ级,采用荧光免疫法定量测定患者血清BNP水平、彩色超声心动图测定左室射血分数(LVEF),分析BNP水平与不同病情的关系。结果:BNP水平随着病情加重而逐渐升高,且与心功能的级别、冠脉的病变呈正相关(分别为r=0.82,P<0.05;r=0.68,P<0.05),与左室射血分数呈负相关(r=-0.53,P<0.05)。结论:BNP是检测心功能衰竭和冠脉病变的重要指标,对临床病情的评估具有重要价值。

Objective： To investigate the clinical value of brain natriuretic peptide （BNP） in the evaluation of heart function and degree of the coronary artery disease in the angina pectoris patients. Methods： 68 patients of angina pectoris which was diagnosed by selected coronary angiography （CAC） were selected, including 32 stable angina patients and 36 unstable angina patients, whose heart function were classified to Ⅰ～Ⅳ based on NYHA. The difference of plasma BNP level was measured by fluomimmunoassay, and left ventricular ejection fraction （LVEF） was detected by color Doppler and the relationship between the BNP level and the different coronary artery lesion was analyzed. Results： The level of plasmaBNP elevated in these patients with the increase of the degree of lesion. It was positively correlated with the degree of coronary lesion and heart function （r = 0.82,P 〈 0.05;r = 0.68,P 〈 0.05 respectively）, and negatively correlated with LVEF （r = -0.53,P 〈 0.05）. Conclusion： The level of plasma BNP is a useful marker for diagnosis of heart failure and coronary artery disease, and have great value for the evaluation of these diseases.