接骨续筋颗粒促进骨折愈合临床疗效观察

Clinical Observation on Effect of Jieguxujin Granule in Promoting Union of Fracture

目的观察接骨续筋颗粒促进骨折愈合的临床疗效及对患者血清中降钙素基因相关肽(CGRP)含量的影响。方法将400例骨折患者随机分为2组。观察组200例,口服接骨续筋颗粒;对照组200例,口服三七伤药片。每3天用放免法检测患者血清中CGRP含量变化,连续检测量5次。每周行X摄片1次观察骨痂形成。结果观察组在临床愈合时间及连续性骨痂形成时间明显少于对照组,差异显著(P<0.005),不同时间CGRP含量变化观察组明显高于对照组(P<0.05或P<0.01)。结论接骨续筋胶囊有明显的促进骨折愈合作用,并能提高患者血清中CGRP含量。

Objective To study the clinical effect of Jieguxujin granule （JGXJG） on fracture and its effect on serum content of calcitonin gene related peptide （CGRP）. Methods Four hundred patients with fracture were randomly divided into 2 groups, the JGXJG treated group and the control group treated with Sanqi tablet （SQT）. Serum CGRP was tested with radioimmunoassay once every 3 days for 5 times, and X-ray examination was taken once each week for 10 weeks. Results The healing time of fracture and osteotylus forming time in the JGXJG group was shorter than those in the SQT group significantly （P 〈 0.005）. Serum CGRP content in JGXJG group was higher remarkably （P 〈 0.05, P 〈 0.01 ）. Conclusion JGXJG showed evident effect in promoting union of fracture healing, it could also increase the CGRP content in serum.