细胞凋亡抑制因子在心肌病血清中的表达

Expression of cell apoptosis inhibiting factor in patients with cardiomyopathy

目的探讨细胞凋亡抑制因子对心肌病的影响和作用机制。方法运用细胞免疫学方法,检测了66例心肌病患者细胞凋亡抑制因子APO-1/Fas和调节因子IL-6,TNFa等指标。结果心肌病各组APO-1/Fas,IL-6,TNFa等指标较对照组有不同程度升高,心功能愈差,升高愈明显。结论APO-1/Fas,IL-6,TNFa等细胞凋亡抑制因子在心肌病细胞凋亡病变中有明显抑制或调节作用。

Objective To study the change of cell apoptosis inhibiing factor（CAIF） in patients with cardiomyopathy.Methods Apo- 1/Fas （CD95）, interleukin - 6（ IL- 6）, and tumour necrosis factor α（TNFα） were assayed by molecular immunology and Doppler eehocardiography was performed in 66 patients with cardiomyopathy. Results The levels of Apo/Fas , IL - 6, and TNFα were higher than those in norreal subjects （ P 〈 0.01）. Cardiac function declined with increasing Apo - 1/Fas, IL - 6 and TNFα. Conclusion High levels of Apo - 1/ Fas, IL - 1, and TNFα might be a pathophysiolgic basis of patients with cardiomyopathy.