清热解毒养阴法治疗面部糖皮质激素性皮炎临床疗效及对皮肤屏障功能的影响

Clinical Effect of Treatment for Clearing Heat, Detoxicating and Nourishing Yin on Patients with Glucocorticosteroid Induced Facial Dermatitis and Its Effect on Skin Barrier Function

目的研究清热解毒养阴法治疗面部糖皮质激素性皮炎的临床疗效及对皮肤屏障功能的修复作用。方法115例患者随机分为治疗组68例和对照组47例,治疗组服用清热解毒养阴法中药,对照组口服氯雷他定片10mg,每日1次,酮替芬片1mg,每晚1次。测定患者治疗前后的经皮水份丢失量(transepider-malwaterloss,TEWL)。结果治疗组有效率为77·9%(53/68例),对照组有效率14·9%(7/47例),治疗组疗效明显优于对照组(P<0·01)。治疗组TEWL的降低优于对照组(P<0·01)。结论清热解毒养阴法治疗面部糖皮质激素性皮炎具有明显的临床疗效和修复皮肤屏障功能的作用。

Objective To observe the clinical efficacy of treatment for clearing heat, detoxicating and nourishing Yin （abbr. as CHM） on glucocorticosteroid （GCS） induced facial dermatitis, and its effect in repairing skin barrier function. Methods One hundred and fifteen patients were randomly assigned into two groups, 68 in the treated group treated with CHM and 47 in the control group treated by oral administration of loratadine 10 mg once a day and ketotifen 1 mg once every night, The volume of transepidermal water loss （TEWL） of patients was measured before and after treatment. Results The effective rate was 77.9 % （53/68 例 ） and 14.9 % （7/47 例 ） in the treated group and the control group respectively, showing significant difference between the two groups, and it was better in the treated group than that in the control group （P 〈 0.01）, The decrease of TEWL in the treated group was also superior to that in the control group （P 〈 0.01）. Conclusion Chinese herbal treatment for clearing heat, detoxicating and nourishing Yin has significant clinical efficiency on GCS induced facial dermatitis and in repairing the skin barrier function.