摘要
辅酶Q10是一种膳食补充剂,在人体细胞呼吸链的电子传递中起重要作用,采用纳米胶囊技术制备辅酶Q10纳米脂质体可提高其生物利用度。本文比较了薄膜-超声法和乙醇注入-超声法对辅酶Q10纳米脂质体包埋效果的影响,结果表明,采用乙醇注入-超声法制得的产品不仅粒径相对较小,而且芯材辅酶Q10的包封率和保留率均高于90%,去除乙醇可显著改善包埋效果。确定水化温度为55℃,水化介质为0.01mol/L磷酸盐缓冲液(pH7.4,0.15mol/LNaCl),产品的平均粒径约为142nm。
Coenzyme Q10 （CoQ10）, as dietary supplement or nutraceutical, is essential for ceil respiration and electron transfer, helping to control the production of energy in ceils, The bioavailability of CoQ10 might be improved when using nanocapsule technology to prepare CoQ^o nanoliposomes. In this study,ethanol injection-sonication method and filming-sonication method were compared, and the former was selected to prepare stable CoQ10 nanoliposomes with higher encapsulation efficiency （EE） and retention rate of CoQ10（〉 90%）, The microencapsulation qualities might be improved evidently by exempting ethanol. Also the relative diameter of the product prepared by the former method was less than that by the latter, The hydration temperature was 55~C and the hydration media were phosphate-buffered saline （0.01mol/L, pH 7,4,0.15mol/L NaCl）. The average diameter was about 142nm by laser light scattering,
出处
《食品工业科技》
CAS
CSCD
北大核心
2006年第2期164-167,共4页
Science and Technology of Food Industry
关键词
辅酶Q10
纳米脂质体
乙醇注入-超声法
包封率
保留率
coenzyme Q10
nanoliposomes
ethanol injection senication method
encapsulation efficiency：
retention rate
