妊娠期肝内胆汁淤积症孕妇血清甘胆酸及胆红素水平与母儿预后的关系

The relationship between the levels of serum cholyglycine and bilirubin and prognosis of mother and fetus in intrahepatic cholestasis of pregnancy

目的:探讨妊娠期肝内胆汁淤积症(ICP)孕妇的血清甘胆酸(CG)、总胆红素(TBil)和直接胆红素(DBil)水平与母儿预后的关系。方法:选择ICP患者70例为研究组,正常孕妇70例为对照组,分别测定孕妇血清甘胆酸(CG)、血清总胆红素(TBil)和直接胆红素(DBil)水平。结果:ICP孕妇血清CG、TBil、DBil水平较对照组明显增高,且产后出血及早产、胎儿窘迫的发生率亦增高。结论:测定孕妇血清CG、TBil、DBil水平可作为预测母儿预后的方法。

Objective ：To investigate the relationship between the levels of serum cholyglycine and totalbilirubin （TBil） and directbilirubin （DBil） and prognosis of mother and fetus in intrahepatic cholestasis of pregnancy （ICP）. Methods：There were 70 pregnant women of ICP in studying group and 70 pregnant women of normal in control group, The levels of serum cholyglycine and TBil and DBil were measured, Results.The levels of serum cholyglycine and TBil and DBil of pregnant women of ICP were significantly higher than those of control group. The incidences of postpartum hemorrhage and premature birth and fetal distress in studying group were higher than those in control group. Conclusion：Measuring the levels of serum cholyglycine and TBil and DBil is a technique for predicting prognosis of mother and fetus in intrahepatic cholestasis of pregnancy.