诺维苯静脉注射致局部毒性反应的预防护理措施

Prevention and nursing measure of toxic reaction caused by navelbine intravenous injection

目的:探讨诺维苯静脉注射致局部毒性反应的预防护理措施。方法:采用在化疗前、后预防性使用2%利多卡因5ml加地塞米松2.5mg静脉推注,以减轻药物对局部组织的不良反应并与化疗前、后不使用任何药物进行比较。结果:前者注射局部红、肿、疼痛、静脉炎的发生率显著减少(P<0.05)。同时,对于已发生局部不良反应的病人使用50%高渗葡萄糖、25%硫酸镁和维生素B12混合液湿敷,外加冰块冰敷局部,对减轻局部组织损伤取得满意疗效,使病人在短时间内恢复正常。结论:积极预防、及时有效的对症处理是减少病人局部损伤和痛苦的关键。

Objective：To investigate the prevention and nursing measure of local toxic reaction caused by navelbine intravenous injection. Methods：In order to reduce the local toxic reaction,2% lidocaine 5 ml and dexamethasone 2.5 mg were used in the research group before and after chemotherapy,and compared with the control group only with chemotherapy. Results：In the control group,The incidence rate of local reaetions,including red, swelling, pain and phlebitis were significantly higher than those in the research group （P〈 0.05）. Moreover, these local toxic reactions could be treated by local application of the mixture of 50% glucose, 25% MgSO4 and vit B12 or ice-bag. Conclusion：Positive prevention and timely heteropathy are the key of reducing the local damage and pain of patients.