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在BLMA_5-Fe^(2+)体系中肌肽对DNA氧化损伤的保护作用

PROTECTION FUNCTIONS OF CARNOSION ON DNA OXIDANT DAMAGE INDUCED BY BLMA_5-Fe^(2+) SYSTEM
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摘要 以BLMA5Fe2+体系切割双链DNA产生MDA物质为基础,采用TBA法检测了肌肽对DNA氧化损伤的保护作用,同时以甘露醇、苯甲酸钠为对照,并对肌肽的抗氧化机理做了初步探讨.结果发现肌肽对DNA损伤的保护作用明显优于甘露醇和苯甲酸钠.其抗氧化曲线与L-组氨酸相似,因此推测其抗氧化性与其所含的咪唑环密切相关. DNA can be cleaved by BLMA5-Fe^2 + system to produce MDA, this DNA damage can be observed by TBA reaction. The antioxidant "abilities of carnosine, L-histidine, β-alanine, Mannitol and Benzoate were studied with TBA method. The protecting mechanism of carnosine in DNA oxidant damage was analyzed. The results suggested that carnosine has a better protective effect than Mannitol and Benzoate in the right system. Its antioxidant curve is similar to L-histidine, which implied that the antioxidant ability of carnosine is closely bound up with its imidazole cycle.
出处 《河南工业大学学报(自然科学版)》 CAS 北大核心 2006年第1期18-20,共3页 Journal of Henan University of Technology:Natural Science Edition
基金 河南省杰出青年科学基金资助项目(0312001500) 教育部科学技术研究重点项目(204086)
关键词 肌肽 DNA BLMA5-Fe^2+体系 氧化损伤 carnosine DNA BLMA5-Fe^2+ system oxidant damage
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参考文献7

  • 1Hipkiss AR.Carnosine,a protective,anti-ageing peptide?[J].Int J Biochem Cell Biol,1998,30:863-868.
  • 2Klebanov GI,Teselkin YO,Babenkova Ⅳ.Effect of carnosine and its components on free-radical reactions[J].Membr Cell Biolj,1998,12:89-99.
  • 3Kantha SS,Wada S,Tanaka H,etal.Carnosine sustains the retention of cell morphology in continuous fibroblast culture subjected to nutritional insult[J].Biochem Biophys Res Commun,1996,223(2):278-282.
  • 4Suzuki H,Mori M,Seto K,etal.Polaprezinc,a gastroprotective agent:attenuation of monochloramine-evoked gastric DNA fragmentation[J].J Gastroenterol,1999,34(Suppl 11):43-46.
  • 5Kang KS,Yun JW,Lee YS.Protective effect of L-carnosine against 12-O-tetradecanoyl phorbol13-acetate-or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells[J].Cancer Lett,2002,178 (1):53-62.
  • 6林元藻,邹国林,李鹏.博莱霉素切割DNA反应的定量测定及其影响因素[J].武汉大学学报(自然科学版),1999,45(4):489-492. 被引量:3
  • 7黄进,杨国宇,李宏基,熊程辉,李留安,王政.在Phen-Cu-Vc系统中肌肽对DNA损伤的作用[J].微量元素与健康研究,2004,21(2):1-3. 被引量:7

二级参考文献5

  • 1王爱国,罗广华.羟自由基启动下的脱氧核糖降解及其产物的 TBA 反应[J].生物化学与生物物理进展,1993,20(2):150-152. 被引量:58
  • 2李鹏,武汉大学学报,1997年,43卷,4期,517页
  • 3Peng L I,实验生物学报,1996年,12卷,4期,719页
  • 4Zou Guolin,生命的化学,1994年,14卷,5期,42页
  • 5Wang Aiguo,生物化学与生物物理进展,1993年,20卷,2期,150页

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