糖尿病对冠状动脉旁路移植术患者术后疗效的影响

Impact of Diabetes on Coronary Artery Bypass Grafting Outcome

目的探讨糖尿病对冠状动脉旁路移植术(CABG)患者术后疗效、围术期并发症发生率及院内死亡率的影响. 方法回顾性分析2001年9月～2003年7月482例行CABG患者的临床资料.根据术前是否合并糖尿病分为糖尿病组(n=135)及非糖尿病组(n=347).术后监测所有患者的血糖,并给予胰岛素严格控制血糖.采用单因素及多因素(logistic回归)分析糖尿病与CABG术后疗效、围术期并发症发生率及院内死亡率的关系. 结果糖尿病组术后再次开胸止血率(4.4%)较非糖尿病组(0.9%)显著增高(χ2值=6.769,P=0.009),其他围术期并发症和死亡率等指标两组差别无统计学意义.多因素回归分析显示左心室射血分数<0.40 (OR值=15.96)、再次开胸止血(OR值=32.77)及术后再插管(OR值=124.17)与院内死亡率有关. 结论糖尿病组与非糖尿病组患者行CABG的围术期并发症及死亡率无明显差别,术后严格控制血糖<11.1mmol/L(200mg/dl),可明显减轻糖尿病对院内死亡率及术后并发症发生的不良影响.

Objective To explore the impact of diabetes on coronary artery bypass grafting （CABG） in clinical representations, operative morbidity and mortality in this hospital. Methods Data was collected as a part of prospective registry of CABG through Sep. 2001 to Jul. 2003. Four hundreds and eighty-two patients were recruited. They were divided into diabetic group （n= 135） and non-diabetic group （n=347） depended on if the patients with diabetes or not. All patients were treated with insulin for hyperglycemia. Clinical representations, operative morbidity and mortality in this hospital between two groups were compared by using chi-square tests, t tests and logistic regression. Results Re-exploration in diabetic group was higher than that in non-diabetic group （4.4% vs. 0. 9%; 3（2= 6. 769, P = 0. 009）. There was no significant difference in the operative morbidity and mortality in hospital between two groups. Multi-variance logistic regression showed that the lower left ventricular ejection fraction （〈 0. 40,OR 15.96）, re-exploration （OR 32. 77） and re-intubation （OR 124.17） were the predictors of perioperative mortality in hospital. Conclusions There are no significant difference in the operative mortality and complication between patients with diabetes and patients with non-diabetes. Strict glucose control in perioperative period would reduce hospital mortality and morbidity.