冠心病心绞痛患者血浆B型钠尿肽的临床意义

The Clinical Value of the Plasma BNP in the Coronary Heart Disease Patients with Angina Pectoris

目的探讨心绞痛患者血清B型钠尿肽水平,评估其对心功能以及冠状动脉病变程度的临床应用价值.方法选择稳定型和不稳定型心绞痛患者68例,根据NYHA标准分为心功能Ⅰ～Ⅳ级,采用免疫荧光法定量测定患者血清B型钠尿肽水平,彩色超声心动检查测定左心室射血分数,分析B型钠尿肽的水平与不同病情的关系.结果 B型钠尿肽水平随着病情加重而逐渐升高,它与心功能级别、冠状动脉的病变呈正相关,与左心室射血分数呈负相关.结论 B型钠尿肽是检测心力衰竭和冠状动脉病变的重要指标,对临床病情的评估具有重要价值.

Aim To invesfigate the value of B-type natriuretic peptide （BNP） in the evaluafion of heart funcfion and degrec of coronary artery disease in the angina pectoris patients. Methods 68 patients of diagnosed by selected coronary angiography （CAG）, including 32 stable angina patients and 36 unstable angina patients, whose heart function was Ⅰ～Ⅳ based on NYHA. The relationship between the level of plasma BNP, which was measured by fluoroimmunoaasay, and left ventfieular ejection fraction （LVEF）, which was detected by color Doppler, and degree of coronary artery lesion, was analysed. Results The level of plasma BNP elevated with the aggravation of the heart disease. It was positively correlated with the degree of coronary artery lesion and degrec ofbeart failure （r=0.82, P〈0.05; r=0.68, P〈0.05）, and negatively with LVEF（r =-0.53, P 〈0. 05 ）. Conclusion The level of plasma BNP is a useful marker for diagnosis of heart failure and coronary artery disease, and has great value for the clinical evaluation of the coronary heart disease.