摘要
大量研究表明他汀类药物在心血管疾病一级预防和二级预防中具有显著疗效,并且与低密度脂蛋白胆固醇(LDL-C)降低的幅度密切相关,强化调脂的概念已经受到广泛重视。尽管他汀类药物具有很高的安全性,但大剂量药物治疗对肝脏和肌肉潜在的不良影响倍受关注,如何在强调调脂的同时注意用药的安全性,是目前该领域的重要话题。
Accumulated clinical trials have demonstrated the clinical efficacy of statins, which is closely associated with the magnitude of LDL-C reduction, in primary and secondary prevention of cardiovascular diseases. The concept of intensive LDL-C lowing has been widely accepted. Although statins are classified as a group of drugs with documented safety and tolerability, the potential risk profile in liver and skeleton muscle under the intensive treatment with large dose has drawn great attention.
出处
《基础医学与临床》
CSCD
北大核心
2006年第2期123-126,共4页
Basic and Clinical Medicine
