结直肠癌手术部位感染相关并发症影响因素分析

Surgical site infection associated complications in colorectal cancer patients

目的探讨结直肠癌切口手术部位感染(surgical site infection,SSI)对相关并发症的影响因素。方法对2001-2005年327例临床病理资料完整的结直肠癌手术患者的年龄、性别、体重指数(body mass index,BMI)、糖尿病及其他合并症、手术情况、白蛋白及血红蛋白水平、肿瘤分期、术后住院时间等因素与切口手术部位感染的关系进行分析。结果 327例切口SSI和切口脂肪液化的发生率分别为2．4％(8／327)、12．2％(40／327);肥胖或糖尿病患者切口SSI发生率显著升高(16．8％ vs 10．0％,28．6％ vs 13．7％);发生切口SSI相关并发症的患者术后住院时间显著延长(29．0 d vs 15．8 d)。结论肥胖和糖尿病是影响结直肠恶性肿瘤患者术后发生手术部位感染相关并发症的重要因素,尤其是SSI或切口脂肪液化发生的重要因素。

Objective The purpose of this study is to investigate the factors associated with incisional surgical site infection （SSI） in colorectal cancer. Methods We retrospectively analyzed impacting factors of SSI including age, gender, BMI, diabetes mellitus, operation, albumin levels, hemoglobin levels, tumor staging, and length of stay post-operation in 327 colorectal patients from 2001 to 2005. Results The incidences of SSI and fat liquefaction were 2.4% （8/327）and 12. 2% （40/327） respectively. The incidences of SSI in patients with obesity and diabetes mellitus increased significantly （ 16. 8% vs. 10.0% ,28.6% vs. 13.7% ）. The length of stay in patients with SSI prolonged significantly （29.0 d vs. 15.8 d）. Conclusion Obesity and diabetes mellitus are the most important factors associated with SSI in colorectal cancer patients.