Particularly interesting new cysteine-histidine rich protein expression in colorectal adenocarcinomas

AIM： To study the relationship between particularly interesting new cysteine-histidine rich protein （PINCH） expression and clinicopathological factors in Chinese colorectal cancer patients. METHODS： The expression of PINCH was examined by immumohistochemistry in 141 samples of primary colorectal adenocarcinoma and 92 normal samples of colorectal mucosa. Eighty of the cases had both primary tumour and normal mucosa from the same patients. RESULTS： PINCH was expressed in the stroma of normal mucosa and tumours. PINCH expression in tumourassociated stroma was increased compared to normal mucosa in both unmatched cases （n = 141, x^2 = 85.79, df = 3, P〈 0.0001） and matched cases （n =80, x^2= 45.86, df= 3, P〈 0.0001）. Among 135 tumours with visible invasive margin, 86 （64%） showed stronger PINCH expression at the invasive margin than in the intratumoural stroma. The frequency of PINCH strong expression in mucinous and signet-ring cell carcinomas was higher （52%） compared to non-mucinous carcinomas （29%, x^2=5.13, P= 0.02）. We did not find that PINCH expres- sion was related to patient＇s gender, age, tumour location, tumour size, gross status, histological type, differentiation, invasion depth, lymph node status and Dukes＇ stage （P 〉 0.05）.CONCLUSION： The expression of PINCH was upregulated in colorectal cancers, and especially at the margin of tumours, and further was related to mucinous and signet-ring cell carcinomas. The results suggest that expression of PINCH may be involved in the tumourigenesis and aggressiveness of colorectal cancers.

瞄准：学习在特别地有趣的新 cysteine-histidine 富人之间的关系用汉语的蛋白质(捏) 表示和 clinicopathological 因素渲染表面的癌症病人。方法：捏的表示被 immumohistochemistry 在表面的腺癌和 92 正常颜色取样的三原色的 141 件样品检验表面的粘膜。八十个盒子从一样的病人有主要的瘤和正常粘膜。结果：捏在正常粘膜和瘤的基质被表示。在联系瘤的基质的捏表示在两个无敌的盒子中与正常粘膜相比被增加(n = 141， c2 = 85.79， df = 3， P < 0.0001 ) 并且匹配的盒子(n = 80， c2 = 45.86， df = 3， P < 0.0001 ) 。在有可见侵略边缘的 135 个瘤之中，(64%) 86 比在 intratumoural 基质在侵略边缘显示出更强壮的捏表示。捏的频率在粘蛋白的和图章戒指房间癌的强壮的表示更高(52%) 与 non-mucinous 癌相比(29% ， c2 = 5.13， P = 0.02 ) 。我们没发现那捏表情与病人的性，年龄，瘤地点，瘤尺寸，粗野地位，组织学的类型，区别，侵略深度，淋巴节点地位和 Dukes'stage 有关(P > 0.05 ) 。结论：捏的表示起来在颜色调整了表面的癌症，并且特别在瘤的边缘，并且进一步与粘蛋白的和图章戒指房间癌有关。结果建议捏的那表情可以涉及颜色的 tumourigenesis 和攻击性表面的癌症。