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胃癌前病变中DNA甲基化状态与叶酸 被引量：11

Relationship between status of DNA methylation and folic acid in gastric precancerosis lesions
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摘要 DNA甲基化异常是胃癌发生的重要机制之一,为了能尽早发现并纠正DNA甲基化异常,阻止胃癌的发生,胃黏膜癌前病变中DNA甲基化状态的研究日益受到重视．众多研究表明,胃黏膜癌前病变中多种基因中存在甲基化异常,而且基因的甲基化异常程度与年龄、性别有关,还与胃黏膜上皮细胞是否存在活动性炎症、肠化及幽门螺杆菌感染有关．叶酸缺乏可导致DNA甲基化的紊乱和DNA修复机制效率的减弱, 叶酸摄入量不足患胃癌的相对危险度增高;胃黏膜癌前病变患者体内叶酸不足,黏膜细胞总基因组DNA甲基化水平下降;经叶酸治疗后,体内叶酸升高,黏膜细胞总基因组DNA 甲基化水平上升,异型增生、肠上皮化生明显改善．因此,叶酸缺乏与胃黏膜癌前病变的发生、发展有关,及时纠正叶酸不足,可逆转胃黏膜的病理改变,减少胃癌的发生．
作者 刘丽华 张方信
机构地区 中国人民解放军兰州军区兰州总医院消化科
出处 《世界华人消化杂志》 CAS 北大核心 2005年第23期2770-2772,共3页 World Chinese Journal of Digestology
基金 甘肃省中青年科学技术基金资助项目 No.YS031-A21-023
关键词 胃癌前病变 DNA甲基化 叶酸
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

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二级参考文献45

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共引文献77

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世界华人消化杂志
2005年 第23期

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