摘要
目的:测定考布他丁A4前药(CA4P)的溶解度和油水分布系数。方法:用平衡法测定溶解度,摇瓶法测定油水分布系数,HPLC法测定样品含量。结果:CA4P在25oC下,在纯化水、甲醇中的溶解度分别为349.82、3.5 mg/ml。CA4P的油水分布系数P接近于0。结论:CA4P亲脂性弱,口服不易吸收。
Object： To determine the solubility and partition coefficient of eombretastatin A4 prodrug （CA4P）. Methods： Solubilities in water and in methanol were determined by the equilibrium method, and the partition coefficient in n-caprylic alcohol/water system was measured by shaking flask method with HPLC. Results： At 25℃, the solubility of CA4P in water was 349.8 mg/ml, in methanol was 23.5 mg/ml. The partition coefficient of CA4P was zero. Conclusion： CA4P was not absorbed in the intestinal tract.
出处
《天津药学》
2006年第1期3-4,共2页
Tianjin Pharmacy
