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逆转录聚合酶链反应检测鼻息肉环氧合酶-2mRNA表达 被引量：1

mRNA expression of COX-2 in nasal polyps assayed by reverse transcription polymerase chain reaction
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摘要 目的检测研究环氧合酶-2(cyclooxygenase-,COX-2)mRNA在鼻息肉组织中的表达水平,深入认识鼻息肉炎性发病机制。方法利用逆转录-聚合链反应(RT-PCR反应)检测35例鼻息肉组织及23例下鼻甲标本的环氧合酶-2的表达。结果鼻息肉组织中COX-2mRNA表达明显高于下鼻甲正常黏膜。结论鼻息肉组织中COX-2表达明显增高,鼻息肉发病过程中有前列腺素参与。 [Objective] To detect the expression of cyclooxygenase-2 （COX-2） mRNA in nasal polyps to investigate the mechanism of inflammation in the nasal polyps. [Methods] Reverse transcfiption-polymerase chain reaction （RT-PCR） method was used to determine cyclooxygenase-2 mRNA expression in 35 nasal polyps and inferior turbinates （23 normal controlled group）. [Results] COX-2 expression is remarkably upregulated in nasal polyps compared to normal controlled group. [Conclusions] The results showed that nasal polyp was a chronic reactive inflammatory disease on which prostaglandins play an important role.
作者 林海 李湘平 甄泽年 杨浦文
机构地区 南京军区福州总医院耳鼻咽喉-头颈外科 南方医科大学南方医院耳鼻喉科
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2006年第4期509-511,共3页 China Journal of Modern Medicine
关键词 鼻息肉 环氧合酶-2 前列腺素 逆转录聚合酶链反应 nasal polyps cyclooxygenase-2 prostaglandins RT-PCR
分类号 R765.25 [医药卫生—耳鼻咽喉科]
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参考文献12

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共引文献13

同被引文献7

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中国现代医学杂志
2006年 第4期

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