白细胞介素-2受体及一氧化氮水平与慢性乙肝病情的关系研究

Relationship between expression level of serum sIL-2R and NO and degree of diseases on Chronic Virus Hepatitis B

目的探讨慢性乙型病毒性肝炎患者血清可溶性白细胞介素-2受体(sIL-2R)及一氧化氮(NO)水平与慢性乙肝病情的关系,为判断慢性乙肝病情提供客观参考依据。方法90例慢性乙型肝炎患者按2000年全国病毒性肝炎诊断标准诊断为慢性乙肝轻度35例,慢性乙肝中度32例,慢性乙肝重度23例。以酶联免疫法检测血清sIL-2R水平,同时以硝酸还原酶法检测血清NO水平。结果sIL-2R及NO水平按轻度、中度、重度依次增高。sIL-2R与NO呈正相关。结论血清可溶性白细胞介素-2受体及一氧化氮含量表达与慢性乙肝病情密切相关,联合检测sIL-2R及NO水平可作为判断慢性乙肝病情的客观依据。

[Objective] To explore the relationship between expression level of serum sIL-2R and NO and degree of the diseases on chronic virus hepatitis B , in order to provide objective basis for signs. [Methods] 90 patients including low-grade 35, moderate 32 and severe 23 were out-patients or in-patients . ELISA and reduction of nitric acid techniques were used to detect the levels of sIL-2R and NO. [Results] Experiments showed that the concentrations of sIL-2R and NO were significandy higher at the stage of severeness than those in the moderate group, and the latter were distinctly higher than those at the low-grade stage. The present data suggest that the level of sIL-2R has closely positive relation to serum NO level in patients with chronic virus hepatitis B. [Conclusion] Serum sIL-2R and NO levels were closely related to degree of the diseases on chronic virus hepatitis B.