乙肝患者血清HBVDNA与e系统相关性的研究

Study on Relationship Between Serum HBV DNA and e System in Hepatitis B Patients

用聚合酶链反应检测１３２例ｅ系统阳性慢性乙型肝炎患者血清ＨＢＶＤＮＡ．结果表明，ＨＢｅＡｇ阳性组，ＨＢＶＤＮＡ阳性率达８９．９％；抗－ＨＢｅ阳性组，ＨＢＶＤＮＡ阳性率为６８．３％．ＨＢＶＤＮＡ阳性患者的丙氨酸水平显著高于ＨＢＡＤＮＡ阳性患者，结果表明大部分抗－ＨＢｅ阳性患者体内仍存在ＨＢＶ复制及病情进展．

Serum HBV DNA from 132 chronic hepatitis B patients with positive e-systen was detected by polymerase chain reaction (PCR). The results showed that the positive rate of HBV DNA was 89. 9% in patients with positve HBeAg while that in patients with positive anti-HBe was 68. 3%. Alanine transaminase level was significantly higher in HBV DNA positive patients than that in HBV DNA negative patients. These results indicate that HBV replication still exists and the disease is also progressive in large number of patients with positive anti-HBe.