阿托伐他汀和辛伐他汀对降脂及消退颈动脉斑块疗效的对比研究

Comparison of atorvastatin and simvastatin in hypolipemic effect and atheromatous plaque resolution of carotid artery in senile patients with hyperlipemia

目的:比较阿托伐他汀和辛伐他汀消退老年人颈动脉粥样斑块及降脂疗效。方法:选择存在颈动脉粥样斑块的143例高脂血症的老年患者,随机分为阿托伐他汀组(n=72)及辛伐他汀组(n=71)。阿托伐他汀组每晚服阿托伐他汀10 m g,辛伐他汀组每晚服辛伐他汀20 m g,均连续服药12周。观察其对血脂各项指标(TC、TG、LDL-C、HDL-C)及肝肾功能的影响,并进行颈动脉多普勒超声检查。结果:两药均能降低TC、TG和升高HVD-C,治疗前后比较差异有显著性(P<0.01);同时两药对老年人颈动脉粥样斑块均有一定的消退作用,但阿托伐他汀优于辛伐他汀。结论:阿托伐他汀能明显降低血脂,能消退颈动脉粥样斑块,且阿托伐他汀的降脂和消退斑块疗效优于辛伐他汀。

Objective： To compare the effects of atorvastatin versus simvastatin on lipid-lowering and atheromatous plaque resolution of carotid artery in senile patients with hyperlipemia. Methods： A total of 143 gerOntal patients with hyperlipemia and carotid atheromatous plaques were randomly divided into atorvastatin group （n=72） and simvastatin group （n=71）, and both groups received atorvastatin （10mg/d） and simvastatin （20mg/d） for 12 weeks, respectively. The blood lipid, liver and renal function, and the carotid plaques before and after the treatment were determined by biochemical analyzer and Doppler ultrasonography, respectively. Results： TC and TG levels decreased, and HDL-C contents increased significantly after atorvastatin or simvastatin treatment （P〈0.0l）. The atheromatous plaques of carotid artery in both groups showed obvious resolution, especially in atorvastatln group. Conclusion： The lipid-lowering efficacy and carotid plaque resolution of atorvastatin are superior to those of simvastain in elderly patients with hyperlipemia.