乳腺癌组织中Cerb-B-2、P53表达及意义

Expression of Cerb-B-2 and P53 in Primary Breast Carcinoma

目的探讨Cerb-B-2、P53基因在乳腺癌中的表达与转移及预后的关系。方法采用免疫组织化学(SP法)对乳腺癌Cerb-B-2、P53的表达进行检测。结果Cerb-B-2阳性率为68.4%,P53阳性率为51.8%。Cerb-B-2、P53基因蛋白的表达与腋窝淋巴结转移有关(P<0.01),随临床分期的递增和淋巴结转移数目的增多,其阳性表达率随之增加,差异有统计学意义(P<0.01)。Cerb-B-2与P53在乳腺癌中的表达呈正相关,其共同阳性表达与淋巴结转移差异有统计学意义(P<0.01)。结论Cerb-B-2、P53基因参与乳腺癌的发生发展过程;联合检测Cerb-B-2、P53基因蛋白对预测乳腺癌淋巴结转移及判断预后有重要意义。

Objective To study the expression of oncogenes Cerb - B - 2 and P53, and the relationship of two genes with metastasis and prognosis in patients with primary breast carcinoma. Methods The expression of Cerb- B- 2 and P53 was detected by immunohistochemical （s- p methods） in 114 cases of breast carcinoma. Results The positive expression of Cerb - B - 2 and P53 were 68.4 % and 51.8 %, respectively, in breast carcinoma, they were correlated with axilliaris lymph node metastasis （P 〈 0.01） .The positive rates Cerb- B - 2 and P53 increased with the number of lymphnode metastasis and the clinicopathological stage （ P 〈 0.01 ）.The expression of Cerb- B - 2 and P53 was correlated positively, farthermore, the co - expression of the two genes was significantly rrelated to lymph node metastasis （ P 〈 0.01 ）. Conclusion Oncogenes Cerb - B - 2 and P53 may play an important role in the development and progression of beast carcinoma. The combined detection of Cerb - B - 2 and P53 geneproteins has positive effects on predicting the lymph node metastasis and the prognosis of breast carcinoma.