庆大霉素在慢性肺心病合并慢性呼吸衰竭时的药代动力学研究

PHAMACOKINETICS FOR GENTAMYCIN IN PATIENTS WITH COR PULMONALE COMPLICATED BY CHRONIC RESPIRATORY FAILURE

本文探讨了21例慢性肺心病合并慢性呼吸衰竭病人及14例无呼吸衰竭的病人对庆大霉素的代谢情况。发现有呼吸衰竭者,应用此药时,其药动参数有明显改变,表现为半衰期延长,消除速率减慢。经计算,认为1日2次静脉给药,每次100mg(10万u),速度为33mg/h较为合适,间隔时间为12h。

We observed the metabolism of gentamycin in patients suffering from cor pulmonale with chronic respiratory failure and 14 other patients without. We found that when gentamycin was used in those who were suffering from respiratory failure, the pharmacokinetic parameters presented marked changes, an extention of the half-life period and a slowing down of the rate of elimination of the drug.These merited our attention in safely and effectively administering gentamycin to patients with cor pulmonale complicated by chronic respiratory failure.After calculation, we think it proper to give this medicine in a dosage of 100 mg (100 000 u) twice daily by i. v. drip at a rate of 33 mg/n, with an interval of 12 h between.