异搏啶对实验性大鼠冠状动脉粥样硬化的作用与机制探讨

STUDY OF THE EFFECT OF VERApAMIL ON EXPERIMENTAL CORONARY ATHEROSCLEROSIS IN RATS AND ITS MECHANISM

本实验探讨了钙拮抗剂异搏啶对维生素D_2加高脂负荷诱发的大鼠冠状动脉粥样硬化的作用。结果表明,异搏啶虽无明显的降血脂、减少主动脉钙盐沉积的作用,但可有效抑制大鼠冠状动脉病灶中平滑肌细胞向泡沫细胞的转化,并降低血小板最大聚集率,扩张冠状动脉,升高胸主动脉环磷腺苷含量。从而提示异搏啶不但对大鼠冠状动脉粥样硬化有预防作用,可能亦有助于防止斑块破裂后的继发血栓形成,预防心绞痛和心肌梗塞的发生。

We studied the effect of calcium antagonist, verapamil, on experimental coronary atherosclerosis in rats loaded with vitamin D2 and cholesterol.Although the drug had little effect in increased plasma lipids and deposition of calcium salts in aorta, however, it markedly inhibited the transformation of smooth muscle cells into foam cells. Verapamil also dramatically reduced the platelet aggregation rate, distended the main branches of coronary arteries and elevated the content of cAMP in the thoracic aorta. It was suggested that verapamil could not only inhibit the formation of atherosclerotic lesions, but was also effective in preventing thrombosis following rupture of plaques and the occurrence of angina pectoris and cardiac infarction.