1Erion MD,Van Poelje PD,Mackenna DA,et al.Livertargeted drug delivery using HepDirect prodrugs[J].J Pharmacol Exp Ther,2005,312(2):554.
2Erion MD,Reddy KR,Boyer SH,et al.Design,synthesis,and characterization of a series of cytochrome P (450) 3A-activated prodrugs(HepDirect prodrugs)useful for targeting phosph(on)ate-based drugs to the liver[J].J Am Chem Soc,2004,126(16):5 154.
3Ye Z,Cheng K,Guntaka RV,et al.Targeted delivery of a triplex-forming oligonucleotide to hepatic stellate cells[J].Biochemistry,2005,44(11):4 466.
4Hashida M,Akamatsu K,Nishikawa M,et al.Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting[J].Pharmazie,2000,55(3):202.
5Akamatsu K,Yamasaki Y,Nishikawa M,et al.Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E(1) using lactosylated poly(L-glutamic hydrazide) as a carrier[J].Biochem Pharmacol,2001,62(11):1 531.
6Tabata Y,Matsui Y,Uno K,et al.Simple mixing of IFN with a polysaccharide having high liver affinity enables IFN to target to the liver[J].J Interferon Cytokine Res,1999,19(3):287.
7Kramer W,Wess G,Schubert G,et al.Liver-specific drug targeting by coupling to bile acids[J].J Biol Chem,1992,267(26):18 598.
8Lehmann TJ,Serwe M,Caselmann WH,et al.Design and properties of hepatitis C virus antisense oligonucleotides for liver specific drug targeting[J].Nucleosides Nucleotides Nucleic Acids,2001,20(4～7):1 343.
9Lehmann TJ,Engels JW.Synthesis and properties of bile acid phosphoramidites 5'-tethered to antisense oligodeoxynucleotides against HCV[J].Bioorg Med Chem,2001,9(7):1 827.
10Romero MR,Martinez-Diez MC,Larena MG,et al.Evidence for dual effects of DNA-reactive bile acid derivatives(Bamets) on hepatitis B virus life cycle in an in vitro replicative system[J].Antivir Chem Chemother,2002,13(6):371.
