白三烯B_4的生物合成及其抑制剂的筛选

BIOSYNTHESIS OF LTB_4 AND SELECTION OF ITS INHIBITORS

花生四烯酸代谢产物白三烯B_4与炎症及过敏反应中白细胞的各种活动密切相关。筛选有效的白三烯B_4抑制荊可为临床提供抗炎抗过敏反应的一代新药。本研究在人血白细胞中孵育花生四烯酸成功地合成了白三烯B_4,并观察了几种植物组份对其合成的影响。实验结果表明,黄芩素为一强力的白三烯B_4抑制剂,分蘗葱头油、生姜油也对白三烯B_4的生物合成呈抑制作用。本研究为把这几种植物组份作为新的抗炎抗过敏药物进行进一步研究提供了线索和理论依据。

LTB4 is one of the metabolites of arachidonic acid via 5-Hpoxygenase pathway.lt is a potent inflammatory mediator and is related to actions of leukocytes in hypersensitive reactions.Our study aimed at finding out some components which inhibit the biosynthesis of LTB4 and offering new drugs which can be used as anti-Inflammatory and anti-allergic agents.Our results showed that baica-lein is a potent inhibitor of LTB4.AVD (Allium cepa L.agrogatum Don)oil and ginger oil also showed inhibitory effects on the biosynthesis of LTB4.This might be significant for the study on anti-inflammatory and anti-allergic drugs.