胃癌患者胃液中5-羟色胺含量的检测及临床意义

EXAMINATION OF 5-HT IN GASTRIC JUICE OF GASTRIC CANCER PATIENTS AND ITS SIGNIFICANCE

本文应用高效液相色谱与荧光分光光度计联机法检测55例胃液内5-羟色胺的含量,共分为正常、溃疡病、萎缩性胃炎、胃癌等4个组。其结果正常组含量为48.70±49.3ng/ml,溃疡病组含量为76.26±127.06ng/ml,慢性萎缩性胃炎组含量为197.29±128.4ng/ml,胃癌组含量为191.80±124.2ng/ml。4组之间进行对比分析,正常组和溃疡病组之间差异不明显(P>0.05),而萎缩性胃炎和胃癌两组与前两组之间差异均显著(P<0.01),但萎缩性胃炎和胃癌之间未见差异(P>0.05)。这充分证明5-羟色胺(5-HT)在萎缩性胃炎和胃癌的胃液中含量是很高的。对于胃癌和慢性萎缩性胃炎的诊断及与其它慢性胃病的鉴别诊断中可能起到很重要的作用。

The content of 5-HT in the gastric juice of 55 patients with gastric diseases was examined with highly effective liquid chromatography combined with fluoro-spectrophotometer. The results showed that the content of 5-HT was 48.70±49.30 ng/ml in the control group, 76.26±127.06ng/rnl in the gastroduodenal ulcer group, 191.80 ±124.80ng/ml in the stomach cancer group, and 197.29 ±128.4ng/ml in the atrophic gastritis group.No significant difference was found between the normal and the gastroduodenal ulcer groups (P>0.05) .Values of the cancer and the atrophic gastritis groups were outstanding among these 4 groups, with a marked significant difference (P<0. 01) .The authors think that these results are of considerable significance in early diagnosis of gastric carcinoma and chronic atrophic gastritis.