种植前牙槽骨保存的动物实验

An experimental study on alveolar ridge preservation prior to dental implant placement

目的探讨外科级半水硫酸钙(SGCS)和富血小板血浆(PRP)复合物在种植前牙槽骨保存中应用的可行性。方法利用SGCS和PRP复合物、SGCS植入5只犬两侧手术区后,采用螺旋CT、放射性核素骨显像、X线片、组织学和组织形态计量技术,比较牙槽骨修复后的变化。结果SGCS和PRP复合物减小了牙槽骨吸收,提高了新骨生成的代谢活性和种植体的骨结合率。而在SGCS中加入PRP仅在早期表现出较高的骨代谢活性。结论在本项实验中,SGCS和PRP复合物可用于种植前牙槽骨的保存。

Objective To evaluate the combination of surgical grade calcium sulfate hemihydrate （SGCS） and platelet-rich plasma （PRP） for alveolar ridge preservation prior to implant placement. Methods Changes of bone quantity andquality in extraction sites following the SGCS/PRP and SGCS implantations were investigated by spiral computer tomography scan, bone scintigraphy, radiographic, histological and histomorphometric examinations. Results The placement of SGCS/PRP reduced the resorption of the alveolar ridge. It also promoted bone metabolism and bone-to-implant contact. The addition of PRP to SGCS achieved the enhancement of the bone metabolism only at the early healing phase. Conclusions In this animal experiment, SGCS/PRP may be used as fresh extraction sockets graft for alveolar ridge preservation prior to implant placement.