多发伤患者严重度与血糖、胰岛素、C肽相关性的临床研究

Changes of blood glucose,insulin and c-peptide in acute multiple-trauma

目的了解多发伤患者急性期血糖、胰岛素、C肽的变化及其临床意义。方法在患者入院后第1、3、7天测定血糖、胰岛素、C肽的水平,并观察急性生理和慢性健康评分Ⅱ(APACHEⅡ)及死亡率之间的关系。结果重创组血糖(15.61±2.21)mmol/L、胰岛素(29.47±7.58)m IU/L、C肽(3.19±1.47)ng/m l均高于对照组(P<0.05),且APACHEⅡ31分以上,死亡率明显增高(36.84%)。结论多发伤急性期血糖、胰岛素、C肽的变化对判断病情严重度有一定意义。

Objective To study the changes of the levels of blood glucose,insulin,c-peptide and their siginificanee in acute multiple trauma. Methods In the 1,3,7d, the levels of serum, blood glucose, c-peptide were determined,and then compare with APACHE Ⅱ Results The levels of blood glucose（ 15.61 ± 2.21 ） mmol/L,serum insulin （29.47 ± 7.58 ）mIU/L,c-peptide（ 3.19 ± 1.47 ）ng/ml in the severe multiple trauma were significantly higher than those in the control group （ P 〈 0.05 ）. The APACHE Ⅱ which was above 31, the morbility were significantly higher that were 36.84%. Conclusion The levels of blood glucose,insulin and c-peptide may serve as an indicator for predicating the severity of traumas.