摘要
目的探讨p27和pERK1/2在胃癌中的表达,意义及二者可能的相互关系。方法免疫组织化学(SP)法检测46例胃癌组织及10例正常胃黏膜中p27和pERK1/2的表达。结果①胃癌组织中p27阳性表达率28.3%(13/46)明显低于正常胃黏膜组织90%(9/10),其表达水平和组织分化程度、胃壁浸润深度、淋巴结转移等有关。②胃癌组织中pERK1/2的阳性表达率47.8%(22/46)明显高于正常胃黏膜组织10%(1/10),其表达水平和胃壁浸润深度、淋巴结转移、TNM分期等有关。③胃癌组织中p27和pERK1/2的表达呈明显负相关。结论ERK1/2基因的活化可以调节p27的表达,二者与胃癌发生发展有关。
Objective To study the expression and its signifinance of p27 and p-ERK1/2 proteins in human gastric carcinoma. Methods The expressions of p27 and p-ERK1/2 proteins in 46 cases of gastric carcinoma and 10 cases of normal tissues were detected by immunohistochemistry technique. Results （ 1 ） Positive expression rate of p27 in gastric carcinoma was 28.3 % （13/46）, which was significantly lower than that in normal tissues（90 %, P 〈 0.01 ）. The expression level of p27 was related to histological differentiation, extent of infiltrating, lymphnode metastasis（ P 〈 0.05）. （2） Positive expression rate of p-ERK1/2 in gastric carcinoma was 47.8 % （22/46）, which was significantly higher than that in normal tissues（ 10%, P 〈 0.05）. The expression level of p-ERK1/2 was related to extent of infiltrating, lymphnode metastasis and TNM stage（ P 〈 0.05）. （3）There was a significant inverse correlation in the expression of p27 and p-ERK1/2 （P 〈 0.05 ）. Conclusion The activity of ERK1/2 can regulate the expression of p27 and both of them may play an important role in the genesis and development of gastric carcinoma.
出处
《胃肠病学和肝病学杂志》
CAS
2006年第1期19-22,共4页
Chinese Journal of Gastroenterology and Hepatology
