胃MALT型淋巴瘤60例临床病理与免疫组化BCL-10的关系

Gastric mucosa-associated lymphoid tissue lymphoma: clinicopathologic and immunohistochemical studies of 60 cases and its relation to BCL-10

目的探讨胃黏膜相关淋巴组织(MALT)型结外边缘区B细胞淋巴瘤的临床病理特点,为诊断和治疗提供依据。方法分析60例胃MALT型淋巴瘤临床、病理形态学特点和免疫组化BCL-10表达情况。结果患者男女比例为1∶1.07,中位年龄52岁。BCL-10核阳性率在淋巴结被累及与未被累及两组间差异非常显著(P<0.01);BCL-10核阳性率在肿瘤局限于黏膜和黏膜下层与浸润肌层至浆膜层两组间差异非常显著(P<0.01);BCL-10核阳性率在不同的临床分期各组间差异显著(P<0.05)。结论BCL-10核表达提示肿瘤的侵袭性增强,可能单纯抗HP治疗无效。

Objective To study the clinical and pathological features of gastric extranodal marginal zone B-cell lymphoma of mneosa-assneiated lymphoid tissue （MALT） type for its diagnosis and treatment. Methods 60 cases of gastric MALT lymphoma were analyzed, including clinical features, stages, pathologic characteristics and nuclear expression of BCL-10 protein by immunohistochemistry. Results The ratio of male to female patients was 1 ： 1.07 with median age of 52 years. The percentage of nuclear positive expression of BCL-10 protein was very significant difference among the patients with different infiltrated depth of tumor and involvement in local lymph nodes as well as various stage. Conclusion The nuclear expression of BCL-10 might be a helpful marker to suggest that the ability of infiltration and dissemination would have been strengthened and non-respensive to antibiotic therapy expected in some cases.