猿猴病毒(SV40)在恶性间皮瘤组织中表达的意义

Expression of simian virus-40 and its significance in malignant mesothelioma

目的探讨恶性间皮瘤组织中SV40是否存在以及该病毒与其预后的关系。方法复习60例经组织学、免疫组化及电镜确诊的恶性间皮瘤。采用PCR方法对恶性间皮瘤组织进行SV40 DNA检测。结果在恶性间皮瘤中可以检出SV40 DNA的存在,检出率为60%。同时分析了组织亚型与SV40表达的关系,结果上皮细胞型与混合型及肉瘤样型之间SV40的表达差异显著(chi-square=5.01,P=0.023),混合型及肉瘤样型更倾向于SV40的阳性表达。结论在我国恶性间皮瘤的发生可能与SV40感染有关,并代表了一种预后不良的趋势。

Objective To study the presence of simian virus-40 （SV40） DNA in tissue sections of malignant mesothelioma and to evaluate the relation of prognosis. Methods We reviewed 60 cases of malignant mesothelioma confirmed by the methods of histology, immunohistochemistry and electron microscopy. The polymerase chain reaction was applied to detect the presence of SV40 DNA in tissue sections of malignant mesothelioma. Results SV40 DNA was detected in the tissue of malignant mesothelioma （60%）. We also analyzed the relation between histology subtype and SV40 expression. SV40 expression was significantly related with mixed and sarcomatoid type （chi-square = 5.01, P = 0.023）. Conclusion The pathogenesis of malignant mesothelioma is probably related with infection of SV40. SV40 positive patients have a trend of unfavourable prognosis.