原发性右心房恶性间皮瘤临床病理观察

Primary malignant mesothelioma of right atrium: a clinicopathologic observation

目的探讨原发性右心房恶性间皮瘤的临床病理学特点及其鉴别诊断。方法对1例右心房恶性间皮瘤进行免疫组化观察并结合文献复习其临床病理特点。结果原发性心房恶性间皮瘤组织形态为瘤细胞向上皮及肉瘤样分化,核分裂象易见,有坏死。免疫表型:calritinin()、Vim()、CK(+)、EMA(+)。结论原发性右心房恶性间皮瘤非常罕见,恶性度高。形态学上应与纤维肉瘤、滑膜肉瘤及转移腺癌等鉴别。免疫组化标记有助于鉴别诊断。

Objective fight atrial （PMMRA） To explore the clinicopathological feature and differential diagnosis of primary malignant mesothelioma of Methods The pathologic changes and immunohistochemical findings in the case of PMMRA were observed with review of literature. Results Microscopically, PMMRA differentiated into epithehoid or sarcoid cell, mitosis and necrosis were easely identified. Immunohistochemically, tumor cells were stained positively for calritinin, vim, CK, EMA, but negatively for SMA, actin. Conclusion PMMRAA is a rare mahgnant tumor with complex morphology. It is necessary to differentiate from fibrosarcoma, synovial sarcoma, metastatic adenocarcinoma etc, morphologically. Immunohistochemistral technique is useful for the diagnosis.