严重烧伤患者血清瘦素水平的改变

Changes of Plasma Leptin Levels in Major Burns and its Significance

目的 分析不同烧伤面积的严重烧伤患者血清瘦素水平改变规律并初步探讨其意义。方法 20例男性严重烧伤患者根据烧伤面积分为30％-50％（n=11）及〉70％总体表面积（n=9）二组，分别于烧伤后第1、3、5、7、14、21、28天采集空腹静脉血，采用放射免疫法检测患者血清瘦素水平。并在入院时记录身高、体重，计算体重指数（BMI）。8例男性健康体检者作为正常对照组。结果 严重烧伤患者血清瘦素水平在烧伤后呈不同程度的降低，烧伤面积〉70％组瘦素水平下降幅度最大（P〈0．01）；死亡患者瘦素水平下降最显著；对照组的血清瘦素水平与BMI呈正相关（r=0．7568，P=0．049），烧伤患者血清瘦素水平与BMI无相关性。结论 大面积烧伤后血清瘦素水平下降，测定烧伤患者血清瘦素水平对判断患者伤情和预后有重要意义。

Objective To analyze the changes in plasma leptin levels after major burns and its significance. Methods Twenty male burned patients were divided into 2 groups according to the total burn surface areas （TBSA） ： 30%-50% TBSA group and 〉70% TBSA group, respectively. Blood samples were collected at 1, 3, 5, 7, 14, 21, and 28 days after burns. Leptin levels were detected with radioimmunosorbent assay, and the body height and body weight were measured to calculate body mass index （BMI）. Results Leptin levels decreased after burns, which were more obvious in the 〉 70% TBSA group （P 〈 0.01 ）, especially in patients who died. There was no correlation between leptin levels and BMI after burn. Conclusion Serum leptin levels decrease in the severely burned patients. Measurement of leptin levels may be useful in determining the severity of the injury and outcome of severely burned patients.