虫草素的化学合成进展

Review on Chemosynthesis of 3'-deoxyadenosine

虫草素第一个从真菌中分离出来的核苷类抗菌素,它具有多种药理活性作用。在国际市场上,虫草素的价格非常昂贵。因此,许多实验室对虫草素的合成进行了研究。本文对虫草素的化学合成方法进行了全面总结,并作出合适的评价和分析。

3＇ - deoxyadenosine is the first nucleoside antibiotic separated from epiphyte, it has many pharmacological activities. In international market, the price of 3＇ - deoxyadenosine is very expensive. As a result, the synthesis of 3 ＇ - deoxyadenosine was investigated in many laboratories. Various chemosynthetic routes of 3＇ - deoxyadenosine were reviewed based on raw material.