PVP包覆β-榄香烯口服脂质体大鼠体内药物动力学研究

Study on Pharmacokinetics of PVP Coated β-elemene Liposome in Rats

目的:研究PVP包覆的β-榄香烯口服脂质体在大鼠体内的药物动力学行为。方法:建立了血浆中β-榄香烯的分析方法,将三种药物对大鼠一次性灌胃后在不同时间眼眶取血。乙醚提取后以气相色谱法定量分析血药浓度,用统计矩方法计算药物动力学参数。结果:PVP包覆β-榄香烯口服脂质体的药物动力学参数如下:T1/2(95.07±20.46)m in,AUC(348.72±32.49)μg/m in.m l,Cm ax(4.39±0.33)μg/m l,Tm ax(60)m in。结论:以普通脂质体为参比制剂时PVP包覆的β-榄香烯口服脂质体相对生物利用度为(140.2±7.5)%。

Objective： To study the pharmacokinetics of PVP eosted β-elemente liposmes in rats. Methods： Gas chromatography was established to determine the concentration of β-elemene in plasma of rats after administered through ig. Results： The pharmaeokineties parameters was. T1/2=95.07 ± 20. 46 min, A UC = 348.72 ± 32.49μg·min/ml, Cmax = 4. 39 ± 0. 33 μg/ml, Tmax = 60 min. Conclusion： The bioavailability of PVP coated β-elemene liposomes is 140. 2 ± 7. 5% compared with conventional linosomes.