蓖麻提取物对鼠抗生育作用的实验研究

Effects of Castor Bean Extract on Antifertility in Mice

利用蓖麻提取物对昆明种小鼠进行了短期与长期的抗生育实验，研究发现蓖麻提取物（蓖麻油和蓖麻蛋白）对小鼠有明显的抗生育作用。蓖麻蚩白及其与蓖麻油的混合物在抗早孕方面的效果均可达到100％，蓖麻油抗着床的效果也可达到100％。蓖麻油长期抗鼠生育效果明显，在210d（正常小鼠的妊娠期是21～23d）内有效降低小鼠生育代数与产仔数，生育抑制率达80％以上。蓖麻提取物对离体小鼠子宫的影响也非常显著，通过增强小鼠子宫内部收缩有效减少着床机率。在中止妊娠的实验中发现，服用了蓖麻蛋白及其与蓖麻油的混合物的小鼠子宫内没有着床位点。

Antifertility experiments have been made on mice for short-term and long-term observation with castor bean extract and ricin, and which showed apparent effects of antifertility. Ricin and the mixture of ricin and castor bean extract respectively showed 100% antiearly pregnancy, while castor bean extract showed 100% anti-implantation. In the field of long-term antifertility, castor bean extract is of good effect which decreased mice＇s production and generations within 210 d （mice＇s normal gestation period is 21～23d）. Besides, significant effects are found in mice＇s isolated uterus with castor bean extract and ricin, which decreased the probability of nidation in the way of strengthening the contraction in uterus. In the experiment of fetation interception, no nidation site was found after the administration of ricin and the mixture of ricin and castor bean extract.