cAMP反应元件结合蛋白与神经退行性疾病

Involvement of cAMP response element binding protein in neurodegenerative disorders

cAMP反应元件结合蛋白(cAMP response elem ent b ind-ing prote in,CREB)是位于细胞核内的转录因子。CREB的活性受到信号通路中许多因子的调控。CREB活化后与真核生物靶基因CRE序列结合并调节其转录,发挥多种生物学效应。在中枢神经系统,CREB调节着神经细胞生长发育,参与神经细胞突触可塑性、长时程记忆的形成过程。CREB参与阿尔采末病、血管性痴呆、亨廷顿舞蹈病及H IV-相关痴呆等神经退行性疾病的病理生理机制研究也取得了进展,成为以CREB作为靶点控制神经退行性疾病病程的理论基础。

cAMP response element binding protein （CREB） is a genetranscription regulator locating in the nucleus. The activated CREB by phosphoration plays an important role by binding to the cAMP response elements and modulate the transcription of various target genes. In addition, the activity of CREB is also regulated by lots of transcriptional regulators in signal transduction mechanism. In central nerve system, CREB participates in promoting neuron growth, the processes of plasticity and long term memory. More importantly, researches of CREB in the pathological processes of Alzheimers disease, Hungtingtons disease and HIV-related dementia have made a progress recently, ding a basis for some therapy strategies to the neurodegenerative disorders. provirelated