TIP30蛋白表达对非小细胞肺癌复发和存活率预测的价值

Relapse or disease-free survival rate prediction value of TIP30 protein expression in NSCLC

背景与目的：TIP30蛋白是一个新发现的抑癌蛋白，在多种肿瘤细胞中表达水平较低，对多种肿瘤细胞的生长有抑制作用。本文旨在探索TIP30蛋白对预测非小细胞肺癌患者复发及存活的价值。方法：利用NSCLC组织标本的蜡块进行免疫组织化学染色，以染色积分同顾性分析与复发、转移及存活的关系。结果：肺脏原发病灶中TIP30蛋白的低表达与临床分期（Ⅰ-Ⅳ期的染色积分分别为2．78±0．10、2．31±0．17、1．96±0．32、0．09±0．63）、患者5年存活率、平均积分[生存期〉5年的为2．14±0．05，高于生存期〈5年的1．87±0．09（P〈0．05）]总体复发率及转移[平均积分术后1年复发或死亡为1．42±0．12，低于术后1年未复发2．36±0．07（P=0.008）]有关，而与组织类型和肿瘤细胞病理学分化程度高低无关。结论：TIP30蛋白可以作为一个预测NSCLC肺癌患者术后复发或转移的分子标记物，为临床上预测肺癌的复发或转移提供新的线索。

Background and Purpose： TIP30 is a newly found tumor suppressing protein that has low level expression in many kinds of tumor cell lines, and it inhibits the growth of tumor cells of different origin. In this article, we want to probe into the value of a newly found tumor suppressor gene TIP30 as a molecular marker for the prediction of relapse or metastasis of lung cancer patients. Methods： In our present study, immunohistochemical analyses of a retrospective database of pathologic specimens were used to demonstrate the expression of TIP30 protein in NSCLC. Results： The low expression of TIP30 protein in NSCLC tumor tissue was statistically significant in the clinical stage, relapse or metastasis or 5 year disease-free survival rate, whereas low levels of TIP30 expression did not relate to histologic type and histologie differentiation. Conclusions： TIP30 protein may be used as a molecular marker to identify and predict the relapse or metastasis of NSCLC, and may provide a new clue for the clinical doctor to evaluate the prognosis of patients with NSCI,C.