期刊文献+

CGAP:构建肿瘤研究领域的生物信息技术平台

The cancer genome anatomy project: building a bioinformatics index in cancer research fields
下载PDF
导出
摘要 美国癌症研究所在1996年发起了癌肿基因组解剖计划(CGAP),其目的在于创建一系列工具以获知与肿瘤相关的基因、蛋白质及其它生物标记物。近年来,生物信息技术的发展为其计划的实施提供了丰富的生物信息资源。常用的生物信息技术有:表达序列标签(EST)、Un igene、基因表达系列分析(SAGE)和数字化差异表达(DDD),四种方法各有其优势,共同成为生物信息技术的组成部分。本文综述了上述生物信息技术在CGAP中的应用,并预测了其未来的发展趋势。 National Cancer Institute initiated the project of building the cancer genome anatomy project in order to find a series of indices to retrieve information about genes, proteins and other biological markers related to cancers in 1996. At present, the project has been speeded up with the help of advances in the development of bioinformatics that could provide enormous biological information. Several bioinformations techniques that are commonly used include: Expressed Sequence Tags, Unigene, Serial Analysis of Gene Expression and Digital Differential Display. Each method has its own advantages, which together make up the bioinformatics technology. In this article, we reviewed the application of bioinformaties in cancer research and predict its trend.
作者 张晔 袁媛
出处 《中国癌症杂志》 CAS CSCD 2006年第3期235-239,共5页 China Oncology
基金 国家自然科学基金资助项目(30171054) 国家"十五"科技攻关资助项目(2004BA703B04-02)
关键词 生物信息技术 肿瘤 癌肿基因组解剖计划 bioinformatics, neoplasms CGAP
  • 相关文献

参考文献18

  • 1Kuska B.Cancer genome anatomy project set for take-off[J].Journal of National Cancer Institute,1996,88(24):1801-1803.
  • 2Strausberg RL,Buetow KH,Emmert-Buck MR,et al.The cancer genome anatomy project:building an annotated gene index[J].Trends Genetics,2000,16(3):103-106.
  • 3Lal A,Lash AE,Altschul SF,et al.A public database for gene expression in human cancers[J].Cancer Res,1999,59(21):5403-5407.
  • 4Loging WT,Lal A,Siu IM.Identifying potential tumor markers and antigens by database mining and rapid expression screening[J].Geno Res,2000,10(9):1393-1402.
  • 5www.ncbi.nlm.nih.gov/SAGE/ or www.ncbi.nlm.nih.gov/EST/.
  • 6Hernandez A,Smith F,Wang Q,et al.Assessment of differential gene expression patterns in human colon cancers[J].Ann Surg,2000,232(4):576-585.
  • 7Ismail RS,Baldwin RL,Fang J,et al.Differential gene expression between normal and tumor-derived ovarian epithelial cells[J].Cancer Res,2000,60(23):6744-6749.
  • 8Waghray A,Schober M,Feroze F,et al.Identification of differentially expressed genes by serial analysis of gene expression in human prostate cancer[J].Cancer Res,2001,61(10):4283-4286.
  • 9Lin YM,Furukawa Y,Tsunoda T,et al.Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas[J].Oncogene,2002,21(26):4120-4128.
  • 10Takano T,Hasegawa Y,Matsuzuka F,et al.Gene expression profiles in thyroid carcinomas[J].Br J Cancer,2000,83(11):1495-1502.

二级参考文献5

共引文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部