皮肤真菌感染中的免疫应答

Immune Responses to Cutaneous Fungal Infections

由于各种众所周知的原因,导致免疫功能低下的患者不断增多,真菌感染率逐年攀升,而大多数关于真菌病的免疫学研究多局限于深部真菌感染。针对不同的皮肤真菌感染,对侵犯皮肤的真菌抗原性和机体对病原体的免疫应答加以介绍,并解释了脂溢性皮炎和特应性皮炎与真菌感染的关系。

Due to the increase of malignancies, autoimmune diseases, transplantations, diabetes mellitus and HIV infections, the number of both immunocompromised patients and fungal infections rises to a new level. However, most of the immunologic studies in these fungal infections are restricted to deep mycoses. We review the immunologic studies in various skin fungal infections and summarize the functions of major cells and molecules involved in the immune responses to the fungi invading the skin. Fungal antigenicities and immune responses are described for different cutaneous infection types. Additionally, the relationship between some fungi related diseases, such as seborrhoeic dermatitis as well as atopic dermatitis, and fungal infections is also reviewed.