免疫炎性因子过度表达在脑性瘫痪发病机制中的作用

Role of Overexpressed Proinflammatory Cytokines in the Pathogenesis of Cerebral Palsy

目的探讨免疫炎性因子水平与脑性瘫痪发病机制的关系。方法运用ELISA法检测31名脑瘫患儿和20名健康儿童及37名脑瘫高危因素新生儿(新生儿病例组)和20名正常新生儿的血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的水平。结果脑瘫患儿和脑瘫高危因素新生儿的血清TNF-α和IL-6水平均高于健康儿童和正常新生儿(P<0.05);脑瘫患儿血清TNF-α水平高于脑瘫高危因素新生儿(P<0.05),IL-6水平两组间无显著性差异(P>0.05)。结论免疫炎性因子过度表达在脑性瘫痪的发病机制中发挥重要作用,高水平的免疫炎性因子可能是脑瘫发病的一个独立危险因素。

Objective To investigate the role of overexpressed proinflammatory cytokines in the pathogenesis of cerebral palsy （CP）. Methods Levels of tumor necrotic factor-α （TNF-α） and interleukin-6 （IL 6） in serum of 31 CP children, 20 healthy children （as controls）, 37 neonates with CP risk factors such as hypoxic-ischemic injury and/or perinatal infection, and 20 healthy neonates （as controls） were measured by enzyme-linked immunosorbent assays （ELISA） retrospectively. Results Levels of TNF-α and IL-6 of CP children and neonates with CP risk factors were significantly higher than that of healthy controls （ P 〈0.05）. TNF-α level of CP children was significantly higher than that of neonates with CP risk factors （P 〈0.05）, but there was no significant difference in IL- 6 level between two groups. Conclusion Overexpressed proinflammatory cytokines play an important role in the pathogenesis of CP and may be an independent risk factor of CP.