摘要
L-组氨酸在醛的催化下,可在羧酸溶剂中发生消旋.L-组氨酸在乙酸溶剂中消旋最快,其合适的催化剂应是水杨醛;L-组氨酸以(R)-酒石酸为拆分试剂,在乙酸溶剂中,在水杨醛存在时进行不对称转换,合成了D-组氨酸的酒石酸盐,经处理得到D-组氨酸.在最佳反应条件下,总收率达94.85%,光学纯度>99.5%.
L-Histidine （L-His） could be racemized in carboxylie acids used as solvents in presence of catalyst such as salicylaldehyde. The rate of racemization of L-His was the most rapid in acetic acid. the suitable catalyst is salicylaldehyde. An asymmetric transformation from L-His to D -His through formation of salt with （ R ）- tartaric acid was achieved by using salicylaldehyde as a catalyst for epimerization in acetic acid, and D-Hiso （ R ）-TA salt was obtained. Treatment of the salt gave D-His with optical purity larger than 99. 5% in 94. 85% yield based on the starting material under the optimistic conditions.
出处
《江南大学学报（自然科学版）》
CAS
2006年第1期96-99,共4页
Joural of Jiangnan University (Natural Science Edition)
关键词
L-组氨酸
D-组氨酸
消旋
不对称转换
L-Histidine
D-Histidine
racemization
asymmetric transformation
