寻常型银屑病与载脂蛋白相关性研究

Correlation of apolipoprotein allele with psoriasis vulgaris in the Han nationality of Chinese population

目的探讨我国汉族人寻常型银屑病(PV)与载脂蛋白E(ApoE)等位基因ε2的相关性。方法采用聚合酶链反应限制性长度多态性(PCR-RPLP)方法分析汉族人群中100名健康者和101例PV患者的ApoE基因型,其中,包括Ⅰ型银屑病患者83例,Ⅱ型18例。又按严重程度分为三度(其中轻度31例,中度29例、重度41例)进行探讨。结果在PV组ε3/2基因型和ε2等位基因频率显著高于健康对照组,且ε2等位基因与PV密切关联(RR=2.9096,x2=5.263,P<0.05)。ε3/2基因和ε2等位基因频率还在Ⅰ型银屑病组和中、重度组中分别明显高于Ⅱ型银屑病和轻度组,但无统计学意义。结论:ApoE分子可能在银屑病发病过程中起着重要作用。ε2等位基因可能是PV的-个危险因素,并可能与PV的发病年龄和严重程度有关。PV患者的脂蛋白代谢异常可能是PV病理机制的部分。

Objective To analyze apolipoprotein E allele ε2 correlation with psoriasis vulgaris（PV） in the Han nationality of Chinese population. Methods to use polymerase chain reaction restriction fragment length polymorphison（PCR -RFLP）techniques determine the genotypes of apolipoprotein E（ApoE） in 101 patients with PV and 100 healthy controls from the Han nationality,including 83 patients with type Ⅰ psoriasis and 18 patients with type Ⅱ psoriasis or 31 patients with mild type and 29 patients with moderate type and 41 patients with severe type psoriasis. Results The frequency of ε3/2 genotype and ε2 allele were significantly higher in PV than in healthy controls,and PV was associated with the 2 allele（RR = 2.9096,x^2 =5. 263,P 〈0.05） The tendency to have higher frequencies of ε3/2 genotype and allele 2 was more apparent in the patients with type Ⅰ psoriasis than with type Ⅱ psoriasis,with severe or mederate type than mild type,but these differences fell short of statistical significance. Conclusion the ApoE molecule may play an important role in the development of PV,and apolipoprotein allele 2 may be a new risk factor for PV. Abnormal lipoprotein metabolism was associated with PV.