地氯雷他定治疗慢性荨麻疹临床研究

Clinical research of desloradine in the traatment of chronic urticaria

目的评价地氯雷他定治疗慢性荨麻疹的疗效与安全性。方法采用随机开放平行对照的方法,对78例慢性荨麻疹患者随机分组,分别给予地氯雷他定5mg、西替利嗪10mg,均每日一次口服,观察治疗第14d、第28d的临床疗效及停药1w后的复发率。结果两者第14d、第28d的有效率分别为:地氯雷他定组68.89%和91.11%,西替利嗪组60.67%和84.85%,两者间无显著性差异(P>0.05)。停药1w后复发率,地氯雷他定组28.89%,西替利嗪组36.36%。两者试验过程中均无明显不良反应。结论地氯雷他定、西替利嗪治疗慢性荨麻疹疗效好,安全性高。

Objective The Study was designed to compare the efficacy and safety of desloradine and cetirizine in the treatment of chronic urticaria. Methods A randomized,open - label parallel comparative clinical trial was conducted in 78 patients. They were divided into two groups,treated wiht daily desloradine 5mg,cetirizine 10mg respectively, The therapeutic results were observed on 14th day and 28th day, The recurrent rates were also reoorded one week after discontinuation of treatment. Results There Was similar clinical efficacy among the two drugs. The efficient rates of desloradine and eetirizine were 68.89% ,60. 60%at 14th day and 91.11% ,84,85% at 128 th day, respectively. But there was no significantly statistical difference among the two groups （ P 〉 0. 05 ）. The recurrent rates of desloradine and cetirizine were 28.89% and 36. 36%, respectively. No obvious side - effects appeared during the entire trial. Conciusions Desloradine and cetirizine have high clinical efficacy and safety in the treatment of Chronic urticaria.