复心片对大鼠体内动脉血栓形成及家兔血小板聚集性的影响

Effect of Fuxin Tablet on Thrombus Formation in the Arteries in Rats and Aggregation of the Blood Platelet in Rabbits

目的观察复心片对大鼠体内动脉血栓形成及家兔血小板聚集性的影响。方法采用电刺激大鼠颈总动脉血栓形成法,观察药物对动脉内血栓阻塞时间(OT)的影响。采用正常家兔血小板血浆(PRP),以ADP为促凝剂,通过血小板聚集仪观测血小板聚集曲线,以血小板凝集1min(PAG-1)、3min(PAG-3)、5min(PAG-5)和最大峰值(PAG-M)为观测指标,比较给药各组与空白对照组血小板聚集率。结果复心片高、中剂量组可以延长大鼠颈总动脉OT,复心片体外给药使血小板聚集率明显降低。结论复心片对血栓形成及对ADP所致的血小板聚集有明显的抑制作用。

Objective To investigate the effect of Fuxin tablet on thrombus formation in the arteries in rats and aggregation of platelet in rabbits. Methods To observe the effect of OT in the arteries through electric stimulation of common carotid artery. To observe the aggregation of platelet by using the PRP of the rabbit and ADP as the accelerant. PAG-1, PAG-3, PAG-5 and PAG-M were examined in the normal saline group and high-dose, middle-dose, low-dose groups of Fuxin tablet. Results High-dose and middle-dose groups of Fuxin tablet could prolong OT and decrease the aggregation of platelet. Conclusion Fuxin tablet could significantly inhibit the formation of thrombus in the arteries and maximal aggregation rate of platelet.