海路酮的催化合成研究

Study on catalytic synthesis of heridone

以氨基磺酸为催化剂,通过环己酮和1,3-丁二醇反应合成海路酮,探讨了各种因素对产品收率的影响。实验结果表明,氨基磺酸是合成海路酮的良好催化剂,在酮醇物质量的比为1∶1.5,催化剂用量2.0%,环己烷10mL/0.1mol环己酮,反应时间80min的条件下,海路酮的收率可达96.0%。

Heridone was synthesized from cyclohexanone and 1,3 - butanediol using sulfamic acid as catalyst. The influence factors on the yield of heridone were discussed. The results showed that sulfamic acid was a good catalyst for synthesizing heridone. The yield of heridone was up to 96.0% when molar ratio of cyclohexanone to 1,3 - butanediol was 1 ： 1.5, amount of catalyst was 2.0% ,water- carrying agent was 10 mL/0.1mol cyclohexanone, and reaction time was 80min.