阿是穴刺血对急性痛风性关节炎大鼠模型外周疼痛介质的影响

Effect of pricking blood therapy at Ashi points on peripheral pain mediums in the acute gouty arthritis rat

目的:探讨阿是穴刺血的镇痛机理。方法:将40只大鼠随机分为空白组、模型组、消炎痛组、刺血组,除空白组外,其余各组采用踝关节腔注射尿酸钠溶液复制急性痛风性关节炎模型,其中消炎痛组用消炎痛灌胃,刺血组用阿是穴刺血处理。测定各组大鼠外周疼痛介质K+、去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)的含量。结果:(1)刺血组较模型组外周疼痛介质K+含量明显降低(P<0·01),DA、5-HT含量亦降低(P<0·05)。(2)刺血组与模型组NE含量无差异。结论:阿是穴刺血能有效抑制外周疼痛介质K+、DA、5-HT的释放。

Objective To study the analgesic mechanism of pricking blood therapy at Ashi points in the acute gouty arthritis rat. Methods Forty rats were randomly divided into a blank group, a model group, an indomethacin group and a pricking blood group. Except the blank group, other groups were injected with sodium urate liquor into the ankle cavity to develop the acute gouty arthritis rat model, and the indomethacin group received gastric perfusion of indomethacin, and the pricking blood group were treated with pricking blood therapy at Ashi points. The peripheral pain mediums K^＋ , NE, DA, 5-HT contents were determined. Results The K^＋ , DA, 5-HT contents in the pricking blood group decreased significantly as compared with the model group （P〈0. 01, P（0. 05） ; there was no significant difference in the content of NE between the pricking blood group and the model group. Conclusion Pricking blood at Ashi points can effectively inhibit release of the peripheral pain mediums K^＋ , DA and 5-HT.