N-(2-甲氧羰基-1-甲基)-乙基-(N′-D-乙酰基吡喃型糖)硫脲类化合物的合成及生物活性

Synthesis and Bioactivity of N-(2-Methoxyl carbonyl-1-methyl)-ethyl-(N′-D-acetyl-pyranosyl)-Thiourea

通过5种糖基异硫氰酸酯(4)与β-氨基丁酸甲酯(3)经亲核加成反应,合成了5种N-(2-甲氧羰基-1-甲基)-乙基-(N′-D-乙酰基吡喃型糖)硫脲,所得化合物经元素分析1、H NMR测试技术确证了结构。生测结果表明,该类化合物对烟草花叶病毒(TMV)具有一定的诱导抗性,而对黄瓜花叶病毒(CMV)无诱导抗性。

Five new N-glucosylated compounds were synthesized by condensation of acetyl glycosyl isothiocya- nate with methyl β-aminobutyfic acid ester in benzene under reflux. The structures were confirmed by element analysis and ^1H NMR. The elicitation activities on the natural defense of plants were tested.